Table 4. Relevant histopathological findings.
Observations | Tissue | Groups: | |||
3%INF | 14%INF | 3%NI | 14%NI | ||
Multifocal to coalescing granulomatous infiltrates | Liver | + (7/12) | + (3/12) | 0 (12/12) | 0 (12/12) |
++ (3/12) | ++ (7/12) | ||||
+++ (2/12) | +++ (2/12) | ||||
Spleen | + (2/12) | + (2/12) | 0 (12/12) | 0 (12/12) | |
++ (9/12) | ++ (7/12) | ||||
+++ (1/12) | +++ (3/12) | ||||
Giant multinucleated cells with intra-cytoplasmic concentric lamellar mineral | Liver | 0 (3/12) | 0 (4/12) | 0 (12/12) | 0 (12/12) |
+ (9/12) | + (8/12) |
Severity of the histopathological findings: non-existant (0), mild (+), moderate (++), severe (+++).
(n/n) – Number of animals with the given severity of the histopathological feature within each group.