Table 3.

Comparison of UHR-OCT appearance of various stages of OSSN/other pathologies

Pathology	Diagnostic Features by UHR-OCT	Lesion Image
OSSN	Thickened, hyper-reflective epithelial layer with an abrupt transition from normal to abnormal epithelium. Thicker lesions may exhibit shadowing, obscuring the subepithelial plane.	Figure 2B, 6B, 7B(b), 8B, 9B
OSSN – resolving	Progression toward epithelial normalization: reduced thickness and hyperreflectivity, less distinct transition zone.	Figure 9D
OSSN - resolved	Normalization of epithelial appearance.	Figure 2D, 6E, 7E, 9F
Melanoma/nevi	Normal-thickness or slightly thicker epithelium overlying a subepithelial lesion. The epithelium may have variable hyper-reflectivity. Thick lesions may exhibit significant “shadowing.” NOTE: In nevi, cystic spaces can be seen on UHR-OCT, although this does not exclude malignancy.	Figure 5B
Pterygium	Thin or normal epithelium overlying dense, hyper-reflective, subepithelial lesion. Variable hyper-reflectivity of overlying epithelium.	Figure 3B
Corneal scarring/ Salzmann’s	Normal-thickness epithelium overlying dense, hyper-reflective subepithelial lesion overlying Bowman’s layer.	Figures 4B, 7B(a), 7E

UHR-OCT=Ultra high resolution ocular coherence tomography ; OSSN=ocular surface squamous neoplasia