Figure 1. The estradiol (E)-estrogen receptor (ER) complex may activate gene transcription directly by binding to specific sequences (estrogen response elements, EREs) within the promoter/enhancer regions of target genes or indirectly by physical interaction with other transcription factors, such as activating protein 1 (AP1).
CBP, histone acetyltransferase CREB-binding protein; SRC-1, steroid receptor coactivator-1; AIB1, amplified in breast cancer 1.