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. 2014 Feb;33(2):51–67. doi: 10.5732/cjc.013.10040

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Chinese Journal of Cancer

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.

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Figure 3. — In addition to the switching-defective (SWI)/sucrose non-fermenting (SNF)-BRG1-associated factors (BAF) and SWI/SNF-polybromo-associated BAF (PBAF) complexes, the catalytic subunit BRG1 (or, less frequently, BRM) can associate with several chromatin-remodeling complexes, including transcription coactivators and corepressors. BRG1 can be found in complexes with transcription coactivators and histone-modifying enzymes such as Williams syndrome transcription factor (WSTF)-including nucleosome assembly complex (WINAC) and nucleosomal methylation activation complex (NUMAC). Conversely, BRG1 can be assembled in complexes known to repress transcription and induce gene silencing, such as the nuclear receptor corepressor (N-CoR) and mSin3A/histone deacetylase (HDAC) complexes. Orange: BRG1 subunit; gold: essential subunits; green: nuclear receptor-associated factors; red: DNA replication factors; yellow: actin-related complexes; blue: factors with other functions.