Table 3. Cytotoxic effects of temozolomide (TMZ) and MG-132 alone or in combination on MGMT-positive GSC lines and the parental glioma cell lines.
Cell line | Growth inhibition rate (%) |
||
TMZ | MG-132 | TMZ plus MG-132 | |
U251 | 48.04 ± 1.00 | 15.49 ± 2.12 | 60.65 ± 2.49 |
U251G | 17.48 ± 2.24 | 19.12 ± 4.27 | 62.99 ± 1.07 |
SKMG-4 | 45.06 ± 2.46 | 16.52 ± 4.73 | 57.28 ± 8.35 |
SKMG-4G | 20.44 ± 2.95 | 20.69 ± 3.84 | 60.87 ± 4.87 |
SKMG-1 | 42.39 ± 1.60 | 15.41 ± 1.63 | 54.12 ± 2.07 |
SKMG-1G | 19.33 ± 4.07 | 16.69 ± 1.79 | 57.02 ± 1.53 |
SF295 | 43.72 ± 2.62 | 16.30 ± 4.49 | 55.43 ± 4.35 |
SF295G | 19.18 ± 0.68 | 19.08 ± 3.18 | 57.37 ± 3.20 |
U87 | 45.43 ± 2.97 | 21.08 ± 1.72 | 62.38 ± 3.11 |
U87G | 21.16 ± 1.26 | 24.45 ± 2.12 | 33.94 ± 1.50 |
TMZ, temozolomide; GSC, glioma stem-like cell. Data are presented as mean ± standard deviation (SD) of 3 repeated experiments.