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. 2014 Feb 26;34(9):3419–3428. doi: 10.1523/JNEUROSCI.1982-13.2014

Figure 4.

Figure 4.

Increased expression of p75NTR protein after OGD occurs in a post-transcriptional, translation-dependent mechanism. a, Primary hippocampal neurons show no change in p75NTR mRNA at 4 and 8 h after OGD (n = 3; Student's t test). b, Quantitative real-time PCR for p75NTR mRNA from cortex of animals subjected to MCAO does not show an increase compared with the contralateral control hemisphere. Graphs depict p75NTR mRNA normalized to endogenous control 18S RNA (n = 4; Student's t test). c, OGD in the presence of the transcriptional inhibitor actinomycin D does not decrease induction of p75NTR. d, Densitometry of c (n = 3; ANOVA). e, Application of the translation inhibitor cycloheximide decreases the induction of p75NTR protein after OGD. f, Densitometry of e (n = 3; ANOVA, *p < 0.05). Error bars indicate SEM. n.s., Not significant.