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. 2014 Feb 26;4:4186. doi: 10.1038/srep04186

Figure 3. Assessment of methylation status for APC and CDKN2A in lung cancer cell lines and tumours using MS-HRM.

Figure 3

DNA methylation in the promoter regions of the APC and CDKN2A genes was assessed in 11 lung cancer cell lines and 56 NSCLC tumours using MS-HRM. APC was found in 5 lung cancer cell lines and 14 NSCLC tumours. CDKN2A methylation was detected in 2 lung cancer cell lines and 14 NSCLC tumours. The negative first derivative plots of three representative methylated lung cancer cell lines for APC (Panel A) and CDKN2A (Panel B) and three representative methylated NSCLC tumours for APC (Panel C) and CDKN2A (Panel D) are shown.