Table 2.

Minor allelic frequency and p-value for the Hardy-Weinberg Equilibrium for the control population and for the overall sample of the databases included in the analysis for Factor V Leiden (FVL), prothrombin (PT) 20210A and methylenetetraydrofolate reductase (MTHFR) C677T polymorphisms.

First Author, year of publication	FVL			PT20210A			MTHFR C667A
	MAF	HWE controls	HWE overall	MAF	HWE controls	HWE overall	MAF	HWE controls	HWE overall
Akar, 2000 [16]	0.13	0.476	0.024	0.04	0.096	0.667	0.28	0.345	0.100
Almawi, 2005 [17]	0.12	0.101	0.010	0.03	0.026	0.975	0.33	0.501	0.002
Angchaisuksiri, 2000 [18]	0.00	0.982	0.983	0.00	0.982	0.983	.	.	.
Aznar, 2000 [19]	0.36	0.843	0.794	0.45	0.811	0.619	.	.	.
Bedencic, 2007 [20]	0.06	0.835	0.524	0.07	0.780	0.484	0.33	0.098	0.019
Cantu, 2004 [21]	0.05	.	.	0.09	.	.	0.43	0.235	0.133
Cushman, 2004 [22]	0.04	0.189	0.012	0.02	0.642	0.608	0.34	0.476	0.386
De Stefano, 2003 [23]	0.07	0.174	0.000	0.04	0.486	0.837	.	.	.
Diaz, 2005 [24]	0.05	.	.	0.05	.	.	.	.	.
Ducros, 2009 [25]	0.05	0.936	0.692	0.03	0.806	0.180	0.38	0.513	0.109
Emmerich (1), 2001 [9]	0.04	0.728	0.096	0.04	0.764	0.292	.	.	.
Emmerich (2), 2001 [9]	0.06	0.449	0.105	0.02	0.494	0.171	.	.	.
Emmerich (3), 2001 [9]	0.04	0.744	0.067	0.02	0.798	0.506	.	.	.
Emmerich (4), 2001 [9]	0.05	0.717	0.513	0.02	0.930	0.748	.	.	.
Emmerich (5), 2001 [9]	0.05	0.777	0.313	0.03	0.936	0.723	.	.	.
Emmerich (6), 2001 [9]	0.08	0.701	0.156	0.02	0.780	0.387	.	.	.
Emmerich (7), 2001 [9]	0.04	0.311	0.095	0.06	0.880	0.754	.	.	.
Fernandez-Miranda, 2005 [26]	0.04	.	.	.	.	.	0.42	0.306	0.622
Folsom (1), 2002, 2007 [27, 28]	0.03	0.698	0.523	0.02	0.838	0.657	.	.	.
Folsom (2), 2002, 2007 [27, 28]	0.03	0.717	0.001	0.01	0.810	0.756	.	.	.
Frederiksen, 2004 [29]	0.04	0.761	0.739	0.01	0.998	0.952	0.31	0.369	0.377
Gemmati (1), 1999 [30]	.	.	.	.	.	.	0.48	0.303	0.796
Gemmati (2), 1999 [31]	.	.	.	.	.	.	0.43	0.410	0.893
Ivanov, 2008 [32]	0.07	0.714	0.115	0.02	0.919	0.835	0.35	0.385	0.310
Keijzer, 2002 [33]	0.06	0.459	0.771	0.02	0.726	0.616	0.30	0.362	0.718
Le Cam-Duchez, 2005 [34]	0.02	0.879	0.771	0.04	0.920	0.155	0.34	0.116	0.033
Lichy, 2006 [35]	0.05	0.584	0.734	0.02	0.859	0.674	.	.	.
Martinelli, 2003 [36]	0.05	0.346	0.000	0.04	0.588	0.000	.	.	.
Nizankowska-Mogilnicka, 2003 [37]	0.07	0.879	0.997	.	0.960	0.763	0.23	0.999	0.228
Ogunyemi, 2003 [38]	0.08	0.926	0.526	.	.	.	0.41	0.240	0.042
Oguzulgen, 2009 [39]	0.08	0.588	0.002	0.03	0.791	0.607	.	.	.
Okumus, 2008 [40]	0.09	0.474	0.070	0.02	0.836	0.578	.	.	.
Penco, 2005 [41]	0.03	0.775	0.008	0.04	0.665	0.455	0.44	0.704	0.087
Shmeleva, 2003 [42]	.	.	.	.	.	.	0.36	0.994	0.019
Straczek, 2005 [43]	0.04	0.554	0.705	0.03	0.779	0.584	.	.	.
Torres, 2006 [44]	.	.	.	.	.	.	0.48	0.284	0.678
Vaya, 2003 [45]	0.02	0.843	0.794	0.01	0.811	0.619	.	.	.

MAF: Minor allele frequency; HWE: p-value for Hardy-Weinberg Equilibrium