. Author manuscript; available in PMC: 2014 Aug 1.

Published in final edited form as: Eur J Epidemiol. 2013 Jul 31;28(8):621–647. doi: 10.1007/s10654-013-9825-8

Table 4.

Risk of venous thromboembolic accidents stratified by the type of event in subjects carriers of Factor V Leiden (FVL), prothrombin (PT) 20210A and methylenetetraydrofolate reductase (MTHFR) C677T polymorphism

	Cases/Controls Exposed	Cases/Controls Not exposed	OR^a	CI^a	I-sq (CI), %	p-value^b
All FVL Carriers (Dominant model)
Venous thrombosis (w\o pulmonary embolism)	855/1,063	3,396/14,498	4.49	(3.23-6.24)	75.1 (59.5-84.7)	0.000
Venous thromboembolism	409/1,048	1,959/14,756	3.46	(2.71-4.42)	39.6 (0.0-65.6)	0.043
Cerebral venous sinus thrombosis	53/101	291/2,394	4.14	(2.46-6.97)	34.3 (0.0-77.0)	0.206
Splanchnic venous thrombosis	8/62	200/1,977	1.30	(0.61-2.79)	0.0 (0.0-0.0)	0.819
Other^c	189/90	797/2,871	7.89	(5.99-10.38)	1.3 (0.0-89.7)	0.363

All PT 20210A Carriers Dominant model)
Venous thrombosis (w\o pulmonary embolism)	510/754	3,798/14,900	2.60	(1.94-3.47)	45.5 (0.3-70.2)	0.029
Venous thromboembolism	250/758	2,085/14,894	3.00	(2.30-3.90)	30.2 (0.0-61.8)	0.122
Cerebral venous sinus thrombosis	51/100	303/2,723	4.40	(2.18-8.91)	39.9 (0.0-77.8)	0.155
Splanchnic venous thrombosis	17/78	192/1,969	2.10	(1.17-3.77)	0.0 (0.0-0.0)	0.941
Other^c	92/118	919/2,859	2.62	(1.79-3.84)	26.6 (0.0-92.4)	0.256

MTHFR C677T Homozygous Carriers (Recessive model)
Venous thrombosis (w\o pulmonary embolism)	163/1,021	789/9,367	1.33	(1.03-1.72)	9.1 (0.0-68.0)	0.360
Venous thromboembolism	116/1,033	891/9,453	1.15	(0.82-1.62)	30.9 (0.0-67.0)	0.162
Cerebral venous sinus thrombosis	22/130	164/888	1.34	(0.64-2.82)	35.4 (0.0-75.8)	0.185
Splanchnic venous thrombosis	5/63	13/252	1.92	(0.50-7.45)	nc^d	nc
Other^c	1/6	3/94	3.02	(0.17-54.24)	nc	nc

Odds ratio (OR) adjusted for age and gender; CI: Confidence Interval

from Q-square test, random effects model

multiple, undetermined, unspecified site

nc, not computable