. Author manuscript; available in PMC: 2014 Aug 1.

Published in final edited form as: Eur J Epidemiol. 2013 Jul 31;28(8):621–647. doi: 10.1007/s10654-013-9825-8

Table 7.

Comparative table of tabular meta-analyses published on association between polymorphic variants of VFL, PT202010A, MTHFR and risk of first VTE

	Cases/Controls	Studies included	Endpoint	OR (95% CI)^a	I-squared	Notes
*FVL*
Marjot, 2011 [146]	767/4020	19	CVT^b	2.40 (1.75-3.30)	0.0%	Adults, European descent
Gohil, 2009 [4]	22225/37566	84	VTE^c	4.93 (4.41-5.52)	58.0%	Studies from European/American authors

*PT20201A*
Marjot, 2011 [146]	646/3690	15	CVT	5.48 (3.88-7.74)	0.0%	Adults, European descent
Gohil, 2009 [4]	21605/27947	79	VTE	3.17 (2.19-3.46)	0.0%	Studies from European/American authors
Gohil, 2009 [4]	546/1734	4	VTE	nc^d	nc	Studies from Asian authors PT20201A not found

*MTHFR C677T*
Marjot, 2011 [146]	233/1323	7	1.97	1.83 (0.88-3.80)	68.0%	Adults, European descent
Gouveia, 2010 [147]	382/1217	9	5.48	1.12 (0.80-1.58)	60.5%	-
Gohil, 2009 [4]	13570/20935	50	nc	1.57 (1.23-2.0)	60.0%	Studies from European/American authors
Gohil, 2009 [4]	827/2758	12	nc	1.09 (0.97-1.24)	0.0%	Studies from Asian authors

Odds ratio, 95% Confidence intervals

Cerebral venous thrombosis

Venous thromboembolism

Not computable