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. Author manuscript; available in PMC: 2014 Feb 26.
Published in final edited form as: Future Oncol. 2010 Mar;6(3):391–405. doi: 10.2217/fon.09.172

Figure 3. The human MIS type II receptor gene, with its 11 exons, is larger than the nine-exon type I gene.

Figure 3

They share several similar but not identical features, hence the different shadings, including extracellular ligand binding domains, transmembrane spanning regions and intracellular S/T kinase domains. Both types are required for MIS signaling, and mutations in the type II receptor are associated with phenotypic changes in humans.

MIS: Müllerian Inhibiting Substance; S/T: Serine/threonine.