Figure 6. Mouse ovarian carcinoma (MOVCAR) tumor-initiating cells, also known as SP cells, which can be separated from less tumorigenic NSP cells, respond to MIS in vitro (SP: 86%; NSP: 93%).
SP cells are moderately resistant to doxorubicin (30% inhibition) but are still nearly completely inhibited by MIS.
†p < 0.001.
‡p < 0.0005. MIS: Müllerian Inhibiting Substance; NSP: Non-side population; SP: Side population.