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Illustrates the major pathways of metabolism for chlorpyrifos (CPF). CYP2B6 has the highest CLint for the bioactivation pathway while CYP2C19 has the highest CLint for the detoxification pathway. TCPy (3,5,6-trichloro-2-pyridinol) is a metabolite specific to CPF. DETP (o,o-diethylphosphorothionate) and DEP (o,o-diethylphosphate) are non-specific metabolites of CPF. PON1 (paraoxonase1) is an alpha esterase.
