Skip to main content
. Author manuscript; available in PMC: 2014 Feb 26.
Published in final edited form as: Toxicology. 2012 Jan 18;293(0):115–122. doi: 10.1016/j.tox.2012.01.006

Figure 4.

Figure 4

Biotransformation of CPF to CPF-O (A&B) and TCPy (C&D) (pmol/min/mg) by individual, genotyped HLMs at 10μM CPF and at 0.5μM CPF. Each bar represents an individual HLM assayed in duplicate except samples 3, 6, 7, 17, and 19, which were done in singlet. Specimens 1–11 are CYP2B6*1/*1 and CYP2C19*1/*1, specimens 12 & 15–18 are CYP2B6*6/*6 and CYP2C19*1/*1, specimens 13 & 14 are CYP2B6*6/*6 and CYP2C19*1/*2, and specimens 19–22 are CYP2B6*1/*1 and CYP2C19*2/*2. A color version of this figure is available in the online version of this manuscript.