Fig. 2.

Tadalafil alleviates functional muscle ischemia in a patient with Becker muscular dystrophy (BMD). (A) Tadalafil restores functional sympatholysis in a patient with BMD, as shown by the exercise-induced attenuation of the decrease in muscle oxygenation (HbO₂+MbO₂) with lower body negative pressure (LBNP) (grey oval). (B) In contrast, a placebo is without effect in the same patient, as shown by comparable LBNP responses during rest and exercise (red oval). (C, D) Summary data expressed as a percentage of total labile signal (TLS) (mean ± SEM) from 10 patients with BMD all of whom completed the double-blind cross-over trial on tadalafil (C) and then placebo (D) or vice versa. *P<0.01, treatment condition × exercise condition interaction using a linear mixed-effects model.