Table 1.

PKCα Interacting Partners and Substrates.

Interacting partner	Phosphorylation	Outcome	References	Notes
Vinculin	Tail, at phospholipid-binding site	Stabilization of the open conformation	Ziegler et al. 2002
VASP	Ser157	?	Chitaley et al. 2004
Talin	Multiple	?	Litchfield and Ball 1986	PKC from brain
Filamin A	Ser2152	Facilitates caveolin 1 mediated internalization	Tigges et al. 2003; Muriel et al. 2011
Ezrin	?	Ezrin activation	Ng et al. 2001
Fascin	Ser39	Increased migration, focal adhesion remodeling	Anilkumar et al. 2003	Constitutive interaction with a S39D fascin mutant
SHP2	Ser576 and Ser591	None	Strack et al. 2002
Syndecan-4	Not phosphorylated	Kinase Activation in the presence of PtdIns4,5P2	Oh et al. 1997;
			Horowitz et al. 1999
Integrin β1	?	Integrin internalization through dynamin-1 pathway	Ng et al. 1999
Caveolin 1	?	Internalization	Sukumaran et al. 2002
pp60src	Ser12	?	Gould et al. 1985	PKC from brain
p72syk	?	Enhanced tyrosine kinase activity	Borowski et al. 1998

In the table, ‘?’ indicates an unknown variable.