Table 4.

Number of Carcinogenic Human Papillomavirus (HPV) Types and Risk of Cytologic Abnormalities for All Sampled Women

No. of Types, Age	Specimens, No.	Specimens, Proportion				HSIL
		NILM	ASC-US	LSIL	ASC-H	Specimens, Proportion	ORa (95% CI)
1
All	10 873	0.790	0.107	0.075	0.013	0.014	1.0
≤30 y	8113	0.748	0.125	0.098	0.013	0.015	1.0
>30 y	2760	0.843	0.085	0.046	0.013	0.013	1.0
2
All	3743	0.644	0.170	0.143	0.022	0.021	1.5 (1.2–1.8)
≤30 y	3141	0.625	0.179	0.152	0.023	0.021	1.4 (1.1–1.8)
>30 y	602	0.705	0.139	0.116	0.020	0.020	1.6 (1.1–2.4)
3
All	1211	0.538	0.213	0.196	0.028	0.024	1.7 (1.3–2.4)
≤30 y	1074	0.522	0.222	0.207	0.025	0.025	1.6 (1.1–2.3)
>30 y	147	0.615	0.174	0.144	0.044	0.024	1.8 (.84–4.0)
≥4
All	490	0.481	0.236	0.231	0.032	0.020	1.4 (.83–2.5)
≤30 y	452	0.486	0.236	0.226	0.033	0.019	1.2 (.70–2.3)
>30 y	38	0.420	0.242	0.290	0.016	0.032	2.6 (.55–12)

Abbreviations: ASC-H, atypical squamous cells, rule out HSIL; ASC-US, atypical squamous cells of undetermined significance; CI, confidence interval; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion; NILM, negative for intraepithelial lesion or malignancy.

^a The age-specific risk for infection with 1 carcinogenic HPV genotype were the reference values used to calculate the age-specific risk ratios (ORs) for infections with >1 carcinogenic HPV genotype. P < .0001, by χ² analysis, for the risk of HSIL in women infected with 1 vs those infected with ≥2 genotypes; P > .05, by χ² analysis, for the risk of HSIL in women infected with 2 vs those infected with >2 genotypes.