Table 5.

Number of Carcinogenic Human Papillomavirus (HPV) Types and Risk of Cytologic Abnormalities, Excluding Women Infected With HPV-16

No. of Types, Age	Specimens, No.	Specimens, Proportion				HSIL
		NILM	ASC-US	LSIL	ASC-H	Specimens, Proportion	ORa (95% CI)
1
All	8740	0.799	0.106	0.077	0.010	0.009	1.0
≤30 y	6501	0.758	0.123	0.100	0.009	0.009	1.0
>30 y	2239	0.849	0.084	0.047	0.011	0.009	1.0
2
All	2491	0.657	0.172	0.139	0.018	0.014	1.5 (1.1–2.0)
≤30 y	2049	0.640	0.183	0.145	0.017	0.015	1.6 (1.2–2.3)
>30 y	442	0.707	0.142	0.121	0.020	0.010	1.2 (.63–2.1)
3
All	679	0.553	0.212	0.199	0.020	0.016	1.7 (1.0–2.9)
≤30 y	587	0.525	0.230	0.211	0.015	0.019	2.0 (1.2–3.4)
>30 y	92	0.662	0.144	0.152	0.038	0.004	0.5 (.06–3.5)
≥4
All	183	0.525	0.196	0.226	0.038	0.015	1.6 (.60–4.5)
≤30 y	170	0.550	0.187	0.211	0.040	0.012	1.3 (.40–4.0)
>30 y	13	0.000	0.385	0.538	0.000	0.077	9.4 (1.2–73)

Abbreviations: ASC-H, atypical squamous cells, rule out HSIL; ASC-US, atypical squamous cells of undetermined significance; CI, confidence interval; HSIL, high-grade squamous intraepithelial lesion; LSIL, low-grade squamous intraepithelial lesion; NILM, negative for intraepithelial lesion or malignancy.

^a The age-specific risk for infection with 1 carcinogenic HPV genotype were the reference values used to calculate the age-specific risk ratios (ORs) for infections with >1 carcinogenic HPV genotype. P = .0007, by χ² analysis, for the risk of HSIL in women infected with 1 vs those infected with ≥2 genotypes; P > .05, by χ² analysis, for the risk of HSIL in women infected with 2 vs those infected with >2 genotypes.