Figure 7.

Inoculation with known microbiota inhibits Bordetella pertussis colonization. C57BL/6 mice were treated with enrofloxacin and then inoculated with 5000 colony-forming units (CFU) of Staphylococcus saprophyticus (square), Staphylococcus lentus (cross), Staphylococcus xylosus (triangle), or Klebsiella (diamond). A, Colonization of these organisms was monitored at 0 and 3 days after inoculation and at day 6 after inoculation, 3 days after inoculation of approximately 5000 CFU of B. pertussis. B, B. pertussis colonization on day 6 after inoculation of microbiota and 3 days after inoculation of B. pertussis was determined for each of the groups initially inoculated with individual host microbiota species. When B. pertussis was not detectable, the sample was labeled “ND.” *P > 0.05.