Table 3.
Adjusted odds ratios and 95% confidence intervals relating patient characteristics to receipt of surveillance mammographya, stratified by age at incident breast cancer diagnosis
| Adjusted OR (95% CI)b | |||
|---|---|---|---|
| <50 years (n=724) |
50–64 years (n=1,425) |
65+ years (n=1,816) |
|
| Years of follow-upc | 0.92 (0.89–0.95) | 0.92 (0.90–0.94) | 0.84 (0.82–0.86) |
| Menopausal status at diagnosisd | |||
| Peri- or pre-menopausal | 0.56 (0.33–0.94) | 0.76 (0.58–0.99) | -- |
| Post-menopausal | 1.00 (Referent) | 1.00 (Referent) | -- |
| Body mass index (kg/m2) at diagnosis | |||
| <18.5 | 0.59 (0.17–2.04) | 0.95 (0.45–1.99) | 0.66 (0.41–1.06) |
| 18.5–24.9 | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| 25.0–29.9 | 1.01 (0.78–1.31) | 1.02 (0.83–1.25) | 1.03 (0.89–1.20) |
| 30.0–34.9 | 0.99 (0.70–1.39) | 0.91 (0.72–1.15) | 0.86 (0.72–1.04) |
| 35.0+ | 0.92 (0.66–1.28) | 0.87 (0.69–1.10) | 0.72 (0.56–0.93) |
| Smoking status at diagnosis | |||
| Current | 1.37 (0.84–2.23) | 0.65 (0.50–0.85) | 0.78 (0.55–1.09) |
| Past | 1.26 (0.76–2.10) | 0.85 (0.61–1.18) | 1.07 (0.81–1.40) |
| Never | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| AJCC stage[15] | |||
| I | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| IIA | 1.08 (0.83–1.40) | 0.79 (0.65–0.95) | 0.84 (0.71–1.00) |
| IIB | 1.29 (0.92–1.81) | 0.96 (0.73–1.27) | 0.67 (0.50–0.88) |
| ER/PR status | |||
| ER−/PR− | 0.88 (0.67–1.16) | 0.97 (0.78–1.20) | 1.09 (0.88–1.35) |
| ER+/PR− | 0.62 (0.38–1.00) | 0.94 (0.72–1.22) | 0.94 (0.75–1.18) |
| ER−/PR+ | 0.94 (0.47–1.87) | 0.60 (0.27–1.35) | 1.00 (0.53–1.87) |
| ER+/PR+ | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| ER & PR unknown | 0.90 (0.51–1.61) | 0.92 (0.64–1.32) | 0.97 (0.74–1.28) |
| Surgical procedure Mastectomy +/− | |||
| radiation | 0.53 (0.41–0.68) | 0.54 (0.45–0.65) | 0.68 (0.59–0.79) |
| BCS + radiation | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| BCS | 0.81 (0.59–1.11) | 0.69 (0.54–0.88) | 0.57 (0.46–0.72) |
| Age (yrs)c | |||
| <40 | 0.64 (0.47–0.89) | -- | -- |
| 40–44 | 0.95 (0.74–1.21) | -- | -- |
| 45–49 | 1.00 (Referent) | -- | -- |
| 50–54 | -- | 1.00 (Referent) | -- |
| 55–59 | -- | 0.91 (0.70–1.19) | -- |
| 60–64 | -- | 0.84 (0.63–1.11) | -- |
| 65–69 | -- | -- | 1.00 (Referent) |
| 70–74 | -- | -- | 0.83 (0.69–1.00) |
| 75–79 | -- | -- | 0.61 (0.50–0.74) |
| 80+ | -- | -- | 0.36 (0.29–0.43) |
| Type of provider seenc | |||
| Oncologist only | 1.83 (1.03–3.25) | 1.49 (0.90–2.45) | 1.46 (0.92–2.31) |
| PCP only | 1.73 (1.21–2.49) | 1.18 (0.84–1.66) | 1.30 (1.00–1.68) |
| Both | 2.14 (1.48–3.11) | 1.67 (1.19–2.35) | 1.89 (1.44–2.47) |
| Neither | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| Charlson co-morbidity index scoree | |||
| 0 | 1.00 (Referent) | 1.00 (Referent) | 1.00 (Referent) |
| 1 | 0.69 (0.56–0.87) | 0.87 (0.75–1.03) | 0.84 (0.74–0.95) |
| 2+ | 0.63 (0.38–1.05) | 0.85 (0.68–1.06) | 0.74 (0.63–0.87) |
Abbreviations: OR=odds ratio; 95% CI=95% confidence interval; AJCC= American Joint Committee on Cancer; PCP=primary care physician; ER=estrogen receptor; PR=progesterone receptor; BCS=breast conserving surgery
0.7% of surveillance mammography includes breast MRI
Adjusted by all variables in the table
Covariate updated each surveillance year
There was only one post-menopausal woman ≥ 65 years at diagnosis so we could not assess menopausal status within this age strata
Time-varying covariate: variable exposure was ascertained throughout the entire study period; once the subject met the variable definition for use, she was included in that category and remained there until the end of follow-up