Fig. 2.
Schematic diagram of the procedure for identification of master regulators and construction of regulatory network for functionally related genes. (A) Identification of master regulators in the trans-eQTL hotspots by eQTL mapping. (B) eQTL map of functionally related genes. (C) The process of seeking master regulators and their targets according to the expression correlation between putative regulators and candidate targets for constructing a regulatory network (see main text for details).