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. 2013 Nov 21;25(3):547–563. doi: 10.1681/ASN.2012101014

Figure 2.

Figure 2.

Diabetic nephropathy is increased in Cd73−/− mice. Cd73−/− mice and age-, weight-, and sex-matched wild-type mice were subjected to STZ-induced diabetes for 16 weeks until measurement of (A) renal adenosine content, (B) body weight, (C) kidney weight, (D) urine volume, (E) drink volume, (F) GFR, (G) albumin excretion, (H) renal nephrin transcript, (I) renal VEGF transcript, (J) and urine MCP-1 (n=6–8 in each group). (K) Extracellular matrix deposition as determined by PAS staining. PAS staining was increased in diabetic wild-type (WT) mice and in particular in Cd73−/− mice (arrows; original magnification, ×400). (L) Histologic score of PAS staining sections. (M) Glomerular size in all groups. (N) Mesangial expansion. M and N show the result of 30 glomeruli in sections of six mice per group. DM, diabetes mellitus; n.s., not significant. All data are shown as mean±SD.