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. 2013 Nov 21;25(3):547–563. doi: 10.1681/ASN.2012101014

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Figure 5. — Diabetic nephropathy is increased in Adora2b^−/− mice. Adora2b^−/− mice and age-, weight-, and sex-matched wild-type (WT) mice were subjected to STZ-induced diabetes for 16 weeks before blood and organs were taken for (A) body weight, (B) kidney weight, (C) urine volume, (D) drink volume, (E) GFR, (F) albumin excretion, (G) renal nephrin transcript, (H) renal VEGF transcript, (I) urine MCP-1, and (J) renal HIF1-α transcript (n=6 in each group). (K) Extracellular matrix deposition as determined by PAS staining. PAS staining was increased in diabetic wild-type mice and in particular in Adora2b^−/− mice (arrows; original magnification, ×400). (L) Histologic score of PAS staining sections. (M) Glomerular size in all groups. (N) Mesangial expansion. M and N show the result of 30 glomeruli in sections of six mice per group. DM, diabetes mellitus; n.s., not significant. All data are shown as mean±SD.