Table 1.

Demographic baseline characteristics of participants (all cases and controls were HIV-infected African Americans)

Characteristic	eGFR<60 Cohort					Nephrotic Proteinuria Cohort
	Cases (n=46)	IQR	Controls (n=92)	IQR	P Value	Cases (n=44)	IQR	Controls (n=88)	IQR	P Value
Median age (yr)	50	44, 58	42	33, 49	<0.001	45	37, 52	40	33,48	0.05
Men, n (%)	23 (50)		68 (74)		<0.01	34 (77)		75 (85)		0.24
Median eGFR (ml/min per 1.73 m2)	54.2	49.3, 58.4	105.8	94.9, 125.4	<0.001a	100.7	78.4, 114.9	105.8	93.6, 118.6	0.08
Median UP/Cr (g/g)	0.20	0.1, 0.77	0.10	0.06, 0.149	<0.01	6.37	5.17, 13.00	0.05	0.04, 0.07	<0.001a
Median CD4 count (cells/mm3)	284	165, 607	361	144, 608	0.81	419	255, 554	410	244, 673	0.61
Viral load<50 copies/ml, n (%)	26 (58)		54 (59)		0.30	33 (77)		66 (75)		0.69
Median log10 viral load	1.77	1.69, 3.37	1.69	1.69, 4.14	0.05	1.69	1.69, 2.76	1.69	1.69, 2.27	0.46
Diabetes, n (%)b	7 (15)		10 (11)		0.45	9 (21)		1 (1)		<0.001a
Median fasting blood glucose (mg/dl)	91	83, 97	89	83, 98	0.46	91	76, 108	87	79, 97	0.04a
Hypertension, n (%)b	33 (72)		33 (36)		<0.001	24 (55)		27 (31)		<0.01
HCV infection, n (%)b	13 (28)		14 (15)		0.09	10 (23)		5 (6)		<0.01
Median fasting cholesterol (mg/dl)	189	156, 224	173	150, 202	0.07	189	173, 230	180	164, 201	0.26
Median fasting HDL cholesterol (mg/dl)	43	37, 54	48	38, 56	0.76	46	35, 65	50	41, 61	0.54
Median fasting LDL cholesterol (mg/dl)	110	91, 135	102	77, 123	0.20	105	67, 140	108	90, 125	0.78
Median fasting triglycerides (mg/dl)	146	101, 256	105	75, 150	0.02	161	114, 228	100	74, 138	0.02

IQR, interquartile range.

^aDetermined by Wilcoxon or Fisher exact tests because logistic regression models did not converge.

^bDiagnosis before case/control assignment.