TABLE 3.

Associations of Plasma mtDNA DAMP Levels with SIRS, MODS, and Mortality^*

MtDNA DAMP	No SIRS Tc (n = 8)	SIRS Tc (n = 5)	Fold Increase	No MODS Tc (n = 9)	MODS Tc (n = 4)	Fold Increase	Mortality Relative Risk (95% CI)
COX1	32.1 ± 0.9	29.0 ± 1.2	8.8†	32.6 ± 0.7	27.1 ± 0.7	43.7†	20.4† (1.3–318)
D-Loop	33.1 ± 0.8	28.3 ± 1.1	28.3†	32.9 ± 0.8	27.9 ± 1.3	31.8†	8.0† (1.16–55.2)
ND1	31.9 ± 0.5	30.2 ± 1.4	3.3†	32.5 ± 0.7	28.2 ± 0.7	19.0†	8.0† (1.15–55.8)
ND6	32.4 ± 0.6	28.9 ± 1.1	11.0†	32.5 ± 0.5	27.6 ± 0.8	30.3†	20.4† (1.3–318)

MtDNA DAMP levels for 4 sequences of interest were examined, segregating patients by the presence of SIRS and MODS, with statistically significant differences in each sequence. As each PCR cycle represents a doubling of DNA quantity, fold increase thus describes the relative starting quantity of mtDNA DAMPs in patients with each syndrome versus those without. Mortality relative risk describes the increased risk of mortality for having a below-median Tc; in this cohort, the median Tc ≈ 30 for each mtDNA DAMP examined.

^*Day 6 data excluded to minimize survivor bias.

^†Statistically significant difference at P < 0.05 by nonparametric analyses.