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. Author manuscript; available in PMC: 2014 Feb 26.
Published in final edited form as: Nat Commun. 2011;2:306. doi: 10.1038/ncomms1304

Figure 6.

Figure 6

Evidence for glutamatergic synaptic transmission between sra-6 expressing neurons and AVA. (a) Reversal of synaptic currents in AVA by clamping the neuron at holding potentials from −95 mV to +65 mV. (b) Peak synaptic current versus holding potential in 10 AVA neurons. A linear fit indicates a reversal potential of −7.0±3.2 mV. (c) Typical spontaneous and evoked synaptic currents recorded from AVA in normal saline, during the bath application of glutamate blockers CNQX (200 μM) and MK-801 (50 μM), and following washout with normal saline. The photo stimulus is indicated by the blue bar. (d) Glutamate blockers reduced the average onset transient during the stimulus (pooled a,c vs. b, p=0.0009; a vs. c, p = 0.622). (e) Glutamate blockers reduced the average sustained current during the stimulus (pooled a,c vs. b, p=0.0007; a vs. c, p = 0.575). (f) Glutamate blockers reduced the average unitary event frequency during the stimulus (pooled a,c vs. b, p=0.003; a vs. c, p = 0.375). Statistics (d–f): within-subjects ANOVA (n = 10) with orthogonal planned comparisons. The joint level of significance (α) was 0.025 throughout. Error bars are SEM.