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IL-1β maturation is independent of ASC but dependent on caspase-1/caspase-11 and caspase-8. Immunoblots of SN and XT from WT, Asc−/−, and Casp1/11−/− (A) or from Ripk3+/− Casp8+/−, Ripk3−/− Casp8+/− and Ripk3−/− Casp8−/− (B) BMDM treated with DMSO, TM, or TG for 4h and then stimulated with LPS for 18h. Data are representative of at least 3 independent experiments.
