Table 3.

Connections Demonstrating Treatment × Time Interactions

Connection Strength With Seed in the Posterior Cingulate Cortex	MNI Coordinate			Cluster Size	Interaction Term	Treatment Period	Connection Strength, Mean (SD)

	x	y	z				Placebo	Duloxetine
Right lateral parietal cortex	48	−72	18	233	F = 7.3	Post	0.42 (0.2)	0.27 (0.2)
Right lateral parietal cortex	48	−72	18	233	P = .01	Pre	0.39 (0.2)	0.54 (0.2)
Right midsuperior frontal cortex	42	14	48	274	F = 10.0	Post	0.21 (0.2)	0.02 (0.1)
Right midsuperior frontal cortex	42	14	48	274	P = .004	Pre	0.08 (0.2)	0.14 (0.2)
Right inferior temporal gyrus	64	−10	−32	262	F = 10.8	Post	0.14 (0.1)	−0.02 (0.2)
Right inferior temporal gyrus	64	−10	−32	262	P = .003	Pre	0.13 (0.2)	0.26 (0.1)

Abbreviation: MNI, Montreal Neurological Institute.