Table II.
Associations between community-acquired infections and subsequent risk of LPL/WM
| Infection | LPL/WM cases n (%) | Controls n (%) | Odds Ratios (95% CI)* | p-value |
|---|---|---|---|---|
| Cellulitis | 144 (20.8) | 34426 (17.2) | 1.18 (0.97 - 1.43) | 0.09 |
| Herpes Zoster | 47 (6.8) | 8557 (4.3) | 1.51 (1.12 - 2.04) | 0.007 |
| Within time interval† | ||||
| 13-30 months | 1.22 (0.67 - 2.23) | |||
| 31-48 months | 1.13 (0.56 - 2.28) | |||
| 49-72 months | 1.93 (1.15 - 3.23) | 0.21 | ||
| More than 72 months | 1.79 (1.03 - 3.12) | |||
| p trend | ||||
| Bronchitis | 225 (32.5) | 45215 (22.6) | 1.56 (1.32 - 1.84)‡ | <0.001 |
| Within time interval† | ||||
| 13-30 months | 1.37 (1.03 - 1.83) | |||
| 31-48 months | 1.77 (1.31 - 2.38) | |||
| 49-72 months | 1.67 (1.28 - 2.19) | 0.75 | ||
| More than 72 months | 1.48 (1.12 - 1.96) | |||
| p trend | ||||
| Cold | 25 (3.6) | 7322 (3.7) | 0.92 (0.61 - 1.37) | 0.68 |
| Influenza | 60 (8.7) | 14726 (7.4) | 1.11 (0.85 - 1.45) | 0.45 |
| Laryngitis | 30 (4.3) | 6584 (3.3) | 1.22 (0.84 - 1.77) | 0.29 |
| Pharyngitis | 112 (16.2) | 22472 (11.2) | 1.43 (1.17 - 1.76)‡ | <0.001 |
| Within time interval† | ||||
| 13-30 months | 0.90 (0.55 - 1.45) | |||
| 31-48 months | 1.98 (1.37 - 2.86) | |||
| 49-72 months | 1.55 (1.08 - 2.24) | 0.29 | ||
| More than 72 months | 1.43 (1.00 - 2.03) | |||
| p trend | ||||
| Pneumonia | 145 (20.9) | 30201 (15.1) | 1.42 (1.18 - 1.72)‡ | <0.001 |
| Within time interval† | ||||
| 13-30 months | 1.43 (1.05 - 1.95) | |||
| 31-48 months | 1.40 (0.97 - 2.03) | |||
| 49-72 months | 1.31 (0.92 - 1.87) | 0.83 | ||
| More than 72 months | 1.55 (1.11 - 2.17) | |||
| p trend | ||||
| Sinusitis | 166 (24) | 36249 (18.1) | 1.33 (1.12 - 1.60)‡ | 0.001 |
| Within time interval† | ||||
| 13-30 months | 1.49 (1.10 - 2.03) | |||
| 31-48 months | 1.34 (0.94 - 1.92) | |||
| 49-72 months | 1.02 (0.72 - 1.45) | 0.77 | ||
| More than 72 months | 1.47 (1.10 - 1.97) | |||
| p trend | ||||
| Gingivitis | <11 (<1) | 917 (0.5) | 1.78 (0.80 - 4.00) | 0.16 |
| Gastroenteritis | 19 (2.7) | 5312 (2.7) | 0.95 (0.60 - 1.50) | 0.82 |
| Cystitis | 227 (32.8) | 56813 (28.4) | 1.11 (0.93 - 1.31) | 0.24 |
| Prostatitis § | 62 (18.9) | 16203 (15.3) | 1.20 (0.90 - 1.58) | 0.21 |
| Pyelonephritis | 13 (1.9) | 3529 (1.8) | 0.98 (0.56 - 1.70) | 0.94 |
Legend Observations in which the number of exposed patients is between one and 10, are listed as ‘<11’ to preserve subjects’ anonymity, in accordance with the SEERMedicare data use agreement.
Abbreviations: LPL/WM: Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinaemia
*
Odds ratios were adjusted for age (66-69, 70-74, 75-79, 80-84, and 85-99 years old), gender and year of selection
†
Preceding LPL/WM diagnosis or control selection
‡
Association is significant at P≤0.00357 (Bonferroni correction for 14 comparisons).
§
Restricted to Males. Percentages reflect this restriction