Table 1.
Characteristics of septic emergency department patients eligible for early goal-directed therapy (n=421).
| Thoracic* Central Venous Catheterization | Any-site Central Venous Catheterization (Thoracic or Femoral) | |||||
|---|---|---|---|---|---|---|
| Attempted n=364 |
Unattempted n=57 |
p-value | Attempted n=382 |
Unattempted n=39 |
p-value | |
| Age (yr) | ||||||
| Mean ± SD | 66.1 ± 16.1 | 65.3 ± 16.8 | 0.72 | 66.1 ± 16.0 | 64.6 ± 17.6 | 0.58 |
| Sex | ||||||
| Male (%) | 198 (54.4) | 28 (49.1) | 0.46 | 205 (53.7) | 21 (53.9) | 0.98 |
| Body mass index | ||||||
| Mean ± SD | 27.5 ± 8.4 | 28.2 ± 7.7 | 0.56 | 27.5 ± 8.4 | 28.5 ± 7.2 | 0.48 |
| ≥30 (%) | 100 (27.5) | 18 (31.6) | 0.71 | 102 (26.7) | 16 (41.0) | 0.08 |
| Missing (%) | 9 (2.5) | 2 (3.5) | 9 (2.3) | 2 (5.1) | ||
| Systolic blood pressure | ||||||
| >90 mmHg† (%) | 121 (33.2) | 30 (52.6) | <0.01 | 129 (33.8) | 22 (56.4) | <0.01 |
| Initial serum lactate (mmol/L) | ||||||
| Mean ± SD | 4.1 ± 3.1 | 4.4 ± 3.6 | 0.50 | 4.1 ± 3.1 | 4.5 ± 3.5 | 0.43 |
| Value ≥4.0 (%) | 211 (57.5) | 36 (63.2) | 0.42 | 222 (57.7) | 25 (64.1) | 0.44 |
| Platelet count (k per μL) | ||||||
| Mean ± SD | 221.2 ± 124.0 | 209.1 ± 136.8 | 0.50 | 219.1 ± 123.8 | 224.1 ± 144.9 | 0.81 |
| <50 (%) | 15 (4.1) | 8 (14.0) | <0.01 | 18 (4.7) | 5 (12.8) | 0.03 |
| International normalized ratio | ||||||
| Mean ± SD | 1.7 ± 1.3 | 3.1 ± 4.1 | 0.02 | 1.9 ± 2.1 | 1.7 ± 1.2 | 0.50 |
| ≥2.0 (%) | 39 (10.7) | 13 (22.8) | 0.03 | 49 (12.8) | 3 (7.7) | 0.48 |
| Missing | 139 (38.0) | 16 (28.1) | 142 (37.2) | 13 (33.3) | ||
*
Thoracic central venous catheterization includes access via the internal jugular or subclavian veins.
†
Systolic blood pressure >90 mmHg either independent of or in response to initial crystalloid bolus of 20 mL/kg.