goral(t) |
Oral dose (mol) bioavailable per unit of time which can describe time varying inputs |
gdermal(t) |
Dermal dose (mol) bioavailable per unit of time which can describe time varying inputs |
ginh(t) |
Inhalation dose (mol) bioavailable per unit of time which can describe time varying inputs |
D(t) |
Amounts of cis- and trans-permethrin or cypermethrin (mol) bioavailable at skin surface as a function of time |
GI(t) |
Amounts of cis- and trans-permethrin or cypermethrin (mol) bioavailable in the gastrointestinal tract as a function of time |
R(t) |
Amounts of cis- and trans-permethrin or cypermethrin (mol) bioavailable in the respiratory tract as a function of time |
Bcis(t) |
Burden of cis-permethrin or cypermethrin (mol) in blood and tissues in dynamical equilibrium with blood as a function of time |
Btrans(t) |
Burden of trans-permethrin or cypermethrin (mol) in blood and tissues in dynamical equilibrium with blood as a function of time |
Scis(t) |
Burden of cis-permethrin or cypermethrin (mol) in storage tissues (mol) as a function of time |
Strans(t) |
Burden of trans-permethrin or cypermethrin (mol) in storage tissues (mol) as a function of time |
Mcis-DCCA(t) |
Body burden of cis-DCCA (mol) as a function of time |
Mtrans-DCCA(t) |
Body burden of trans-DCCA (mol) as a function of time |
M3PBA(t) |
Body burden of 3-PBA (mol) as a function of time |
Mnot observed(t) |
Body burden of non-monitored metabolites (mol) as a function of time |
Ucis-DCCA(t) |
Cumulative amounts of cis-DCCA in urine (mol) as a function of time |
Utrans-DCCA(t) |
Cumulative amounts of trans-DCCA in urine (mol) as a function of time |
U3PBA(t) |
Cumulative amounts of 3-PBA in urine (mol) as a function of time |
QUcis-DCCA(t) |
Urinary excretion rate of cis-DCCA in urine (mol) as a function of time = Mcis-DCCA(t)×kMU_cis
|
QUtrans-DCCA(t) |
Urinary excretion rate of trans-DCCA in urine (mol) as a function of time = Mtrans-DCCA(t)×kMU_trans
|
QU3PBA(t) |
Urinary excretion rate of 3-PBA in urine (mol) as a function of time = M3PBA(t)×kMU_3PBA
|
Fcis-DCCA(t) |
Cumulative amounts of cis-DCCA in feces (mol) as a function of time |
Ftrans-DCCA(t) |
Cumulative amounts of trans-DCCA in feces (mol) as a function of time |
F3PBA(t) |
Cumulative amounts of 3-PBA in feces (mol) as a function of time |
fabs_oral_cis
|
Oral absorption fraction of cis-permethrin or cypermethrin |
fabs_oral_trans
|
Oral absorption fraction of trans-permethrin or cypermethrin |
fabs_dermal_cis
|
Dermal absorption fraction of cis-permethrin or cypermethrin |
fabs_dermal_trans
|
Dermal absorption fraction of trans-permethrin or cypermethrin |
kabs_oral_cis
|
Oral absorption rate of cis-permethrin or cypermethrin (h−1) |
kabs_oral_trans
|
Oral absorption rate of trans-permethrin or cypermethrin (h−1) |
kabs_dermal_cis
|
Dermal absorption rate of cis-permethrin or cypermethrin (h−1) |
kabs_dermal_trans
|
Dermal absorption rate of trans-permethrin or cypermethrin (h−1) |
kabs_inh_cis
|
Respiratory absorption rate of cis-permethrin or cypermethrin (h−1) |
kabs_inh_trans
|
Respiratory absorption rate of trans-permethrin or cypermethrin (h−1) |
kBS_cis
|
Blood to storage tissues transfer rate of cis-permethrin (h−1) |
kBS_trans
|
Blood to storage tissues transfer rate of trans-permethrin (h−1) |
kSB_cis
|
Storage tissues to blood transfer rate of cis-permethrin (h−1) |
kSB_trans
|
Storage tissues to blood transfer rate of trans-permethrin (h−1) |
kBM_cis
|
Biotransformation rate of cis-permethrin or cypermethrin into cis-DCCA (h−1) |
kBM_trans
|
Biotransformation rate of trans-permethrin or cypermethrin into trans-DCCA (h−1) |
kBM_3PBA_cis
|
Biotransformation rate of cis- permethrin or cypermethrin into 3-PBA (h−1) |
kBM_3PBA_trans
|
Biotransformation rate of trans- permethrin or cypermethrin into 3-PBA (h−1) |
kBM_NO_cis
|
Biotransformation rate of cis-permethrin or cypermethrin into non-observed cis-derivative metabolites (h−1) |
kBM_NO_trans
|
Biotransformation rate of trans-permethrin or cypermethrin into non-observed trans-derivative metabolites (h−1) |
kBM_NO_3PBA_cis
|
|
|
Biotransformation rate of cis-permethrin or cypermethrin into non-observed cis-phenoxy derivatives (h−1) |
kBM_NO_3PBA_trans
|
Biotransformation rate of trans-permethrin or cypermethrin into non-observed trans-phenoxy derivatives (h−1) |
kMU_cis
|
Transfer rate of cis-DCCA from the body to urine (h−1) |
kMU_trans
|
Transfer rate of trans-DCCA from the body to urine (h−1) |
kMU_3PBA
|
Transfer rate of 3-PBA from the body to urine (h−1) |
kMF_cis
|
Transfer rate of cis-DCCA from the body to feces (h−1) |
kMF_trans
|
Transfer rate of trans-DCCA from the body to feces (h−1) |
kMF_3PBA
|
Transfer rate of 3-PBA from the body to feces (h−1) |
kmetabolism_cis
|
Biotransformation rate of cis-permethrin or cypermethrin into cis-metabolite forms or 3-PBA ( = kBM_cis+kBM_NO_cis) (h−1) |
kmetabolism_trans
|
|
|
Biotransformation rate of trans-permethrin or cypermethrin into trans-metabolite forms or 3-PBA ( = kBM_trans+kBM_NO_trans) (h−1) |
kelim_cis
|
Total excretion rate of cis-DCCA = (kMU_cis+kMF_cis) (h−1) |
kelim_trans
|
Total excretion rate of trans-DCCA = (kMU_trans+kMF_trans) (h−1) |
kelim_3PBA
|
Total excretion rate of 3-PBA = (kMU_3PBA+kMF_3PBA) (h−1) |
ωcis
|
kBM_cis×kMU_cis
|
ωtrans
|
kBM_trans×kMU_trans
|
ω3PBA
|
kBM_3PBA×kMU_3PBA
|