Table 2. Parameter values of the model based on fits to the data of Woollen et al. (1992) on both average and individual urinary excretion time courses of trans-DCCA, cis-DCCA and 3-PBA following an oral and dermal exposure in volunteers.
| Analyte | Parameters | Meana (range)b | |
| Trans-permethrin | Transfer rate constants (h−1) | kBS_trans | 10.4 (10.4–20.8) |
| kSB_trans | 0.072 (0.058–0.186) | ||
| kmetabolism_trans | 20.8 (8.32–41.6) | ||
| (kelim_trans) | 0.157 (0.157–0.650) | ||
| kabs_oral_trans | 0.457 (0.320–0.671) | ||
| kabs_dermal_trans | 0.033 (0.037–0.066) | ||
| % of administered molar dose as trans-DCCA in urine | % related to ωtrans | 18.4 (13.7–23) | |
| Dermal absorption fraction | fabs_dermal_trans | 0.820 (0.63–1.23) | |
| Cis-permethrin | Transfer rate constants (h−1) | kBS_cis | 3.20 (0.457–10.4) |
| kSB_cis | 0.041 (0.045–0.141) | ||
| kmetabolism_cis | 13.9 (2.08–6.93) | ||
| (kelim_cis) | 0.184 (0.277–0.462) | ||
| kabs_oral_cis | 0.317 (0.310–0.473) | ||
| kabs_dermal_cis | 0.047 (0.043–0.052) | ||
| % of administered molar dose as cis-DCCA in urine | % related to ωcis | 9.51 (6.35–11.3) | |
| Dermal absorption fraction | fabs_dermal_cis | 1.25 (0.85–1.99) | |
| 3-PBA | Transfer rate constants (h−1) | (kelim_3PBA) | 0.095 (0.095–0.462) |
| % of administered molar dose as 3-PBA in urine | % related to ω3PBA | 12.9 (9.19–18.8) | |
a
The reported mean parameter values are the values giving the best fit (÷2) to average experimental time course data of Woollen et al. (1992) (n = 6).
b
The range of parameter values reported correspond to the minimum and the maximum parameter values giving the best fit (χ2) to average and individual experimental data of Woollen et al. (1992) from 4 volunteers. Individual parameter values for two volunteers were not selected because of the presence of incomplete voids.