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. 2014 Feb 26;9(2):e89380. doi: 10.1371/journal.pone.0089380

Table 1. Model parameters used in computer simulations of tumor growth and radiotherapy treatments.

Description Symbol Value/Range Source
Migration rate kmig 0.025 h −1/1.75 h −1 [18], [43]
Apoptosis rate Kapt 4.17×10−4 h −1 [32]
Lysis rate Klys 0.035 h −1 (Assumed)
Radiosensitivity (LQ model) α 0.48 Gy −1 [47]
Radiosensitivity (LQ model) β 0.02 Gy −2 [47]
Radiosensitivity (LQ model): Proliferating (CC) ξp 1 1.00 [68], [69]
Radiosensitivity (LQ model): Quiescent (CC) ξq 1 0.85 [68], [69]
Radiosensitivity (LQ model): Proliferating (CSC) ξp 2 0.30 [68], [69]
Radiosensitivity (LQ model): Quiescent (CSC) ξq 2 0.20 [68], [69]
CC cycle duration τcc 26 h [45]
CSC cycle duration τcsc 48 h, 72 h, 96 h (Assumed)
Asymmetric division probability (CSC) pa 0.75, 0.50, 0.25 (Assumed)
Maximum number of cycle divisions (CC) 15 [32], [61]

Values for those parameters not found in the literature were assumed (see detailed explanation for lysis rate). In the remaining cases (asymmetric division probability and CSC cycle duration) some values were assumed, and the impact of different parameter sets on the resulting effects was subsequently analyzed.