Table 1. Model parameters used in computer simulations of tumor growth and radiotherapy treatments.
Description | Symbol | Value/Range | Source |
Migration rate | kmig | 0.025 h −1/1.75 h −1 | [18], [43] |
Apoptosis rate | Kapt | 4.17×10−4 h −1 | [32] |
Lysis rate | Klys | 0.035 h −1 | (Assumed) |
Radiosensitivity (LQ model) | α | 0.48 Gy −1 | [47] |
Radiosensitivity (LQ model) | β | 0.02 Gy −2 | [47] |
Radiosensitivity (LQ model): Proliferating (CC) | ξp 1 | 1.00 | [68], [69] |
Radiosensitivity (LQ model): Quiescent (CC) | ξq 1 | 0.85 | [68], [69] |
Radiosensitivity (LQ model): Proliferating (CSC) | ξp 2 | 0.30 | [68], [69] |
Radiosensitivity (LQ model): Quiescent (CSC) | ξq 2 | 0.20 | [68], [69] |
CC cycle duration | τcc | 26 h | [45] |
CSC cycle duration | τcsc | 48 h, 72 h, 96 h | (Assumed) |
Asymmetric division probability (CSC) | pa | 0.75, 0.50, 0.25 | (Assumed) |
Maximum number of cycle divisions (CC) | – | 15 | [32], [61] |
Values for those parameters not found in the literature were assumed (see detailed explanation for lysis rate). In the remaining cases (asymmetric division probability and CSC cycle duration) some values were assumed, and the impact of different parameter sets on the resulting effects was subsequently analyzed.