Table 1. Standard binding free energies of the TRF DBD domains to telomeric DNA (kcal/mol).
a | ||||
tight,r * = 2.0b | intermediate,r * = 2.4 | loose,r * = 3.0 | ||
TRF1 | −6.8 | −9.8 | −12.5 | −9.2 |
TRF2 | −4.3 | −8.4 | −11.5 | −8.4 |
experimental values taken from Ref. [18].
r * (in nm) denotes a boundary between the bound and unbound state for the three defined binding modes.