Table 4. MM/PBSA binding free energies (kJ/mol) of RIG1/dsRNA and MDA5/dsRNA complexes.

Energy component	RIG1/dsRNA (kJ/mol)	MDA5/dsRNA (kJ/mol)
ΔGcoul	−23858.9 (6.0)*	−26288.4 (5.1)
ΔGps	28789.7 (6.2)	32055.2 (5.6)
ΔGpolar	4930.8	5766.8
ΔGvdW	−3431.18 (1.2)	−3487.69 (1.8)
ΔGnps	−96.0808 (0.3)	−93.3481 (0.5)
ΔGnonpolar	−3527.26	−3581.04
ΔGbind	−1403.5 (3.7)	−2185.78 (3.5)

*Standard errors are indicated in parenthesis.

ΔG_coul = Electrostatic energy.

ΔG_ps = Polar solvation energy.

ΔG_polar = Polar contribution (ΔG_coul+ΔG_ps).

ΔG_vdW = van der Waals energy.

ΔG_nps = Nonpolar solvation energy.

ΔG_nonpolar = Nonpolar contribution (ΔG_nps+ΔG_vdW).

ΔG_bind = Overall binding energy.