Figure 3. β55 Staining of Dot Blots of Synthetic Aβ Aggregates.

(a) Dot blot of synthetic Aβ_1–42 and Aβ_1–40 aggregates probed with biotinylated-β55. (b) Western blot of the synthetic Aβ_1–42 and Aβ_1–40 aggregates probed with 6E10 antibody. The increased staining of Aβ_1–42 aggregates in the dot blot relative to Aβ_1–40 aggregates is consistent with the greater fibril and high molecular weight oligomer composition of Aβ_1–42 aggregates observed in the western blot.