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. 2014 Feb 26;9(2):e89977. doi: 10.1371/journal.pone.0089977

Figure 1. Deletion of SGLT1 results in reduced glucose contents in intestinal tissues and blood.

Figure 1

Sglt1 +/+ (white bars) and sglt1−/− mice (black bars) received an intragastric glucose bolus (4 g/kg) containing radiolabeled D-glucose. After 15 minutes, radiotracer contents in intestinal tissue samples covering the entire small intestine, in plasma as well as blood glucose was measured. (A) Tissue profiling for glucose tracer contents along the small intestine of sglt1 +/+ and sglt1−/− mice. (B) Average accumulation of glucose tracer amounts in 1 cm intestinal tissue samples over 15 minutes. (C) Radiolabeled glucose contents in plasma. (D) Increase in blood glucose after glucose gavage. Values are expressed as mean ± SEM. Statistical analyses for glucose tracer in tissues and plasma were performed using unpaired t-test with Welch’s correction. ** p<0.01. Values of rise in blood glucose are expressed as mean ± SEM. Statistical analyses were performed using unpaired t-test. * p<0.05. N = 4–5 mice per group.