Figure 4. p21 deficiency impacts Chaos3 tumor latency in males and females and tumor susceptibility in females.

Kaplan-Meier graphs of the indicated genotypes and sexes are shown. Mcm4^C3/C3 p21^−/− male and female mice have significantly decreased time to tumor onset than Mcm4^C3/C3 alone. Mcm4^C3/C3 p21^+/− females, but not males, also have significantly decreased tumor latency compared to Mcm4^C3/C3 alone. See statistics in Supplementary Table 2. C3 = Mcm4^C3.