. Author manuscript; available in PMC: 2014 Apr 1.

Published in final edited form as: Mol Imaging Biol. 2013 Apr;15(2):230–237. doi: 10.1007/s11307-012-0583-x

Table 1.

Association between blinded visual assessment and Bielschowsky silver stain, thioflavin S, and qualitative overall pathology read—efficacy population

Reader	Blinded visual assessment	Qualitative Bielschowsky silver stain pathology read		Qualitative thioflavin S pathology read		Qualitative overall pathology read		Sensitivity and specificity

		Abnormal (N=2)	Normal (N=3)	Abnormal (N=2)	Normal (N=8)	Abnormal (N=2)	Normal (N=8)	Sensitivity % (95 % CI)	Specificity % (95 % CI)
Reader 1	Abnormal	2 (100)	0	2 (100)	0	2 (100)	0	Bielschowsky: 100 (16, 100) Thioflavin S: 100 (16, 100)	Bielschowsky: 100 (29, 100) Thioflavin S: 100.0 (63, 100)
Reader 1	Normal	0	3 (100)	0	8 (100)	0	8 (100)	Overall: 100 (16, 100)	Overall: 100 (63, 100)
Reader 2	Abnormal	2 (100)	0	2 (100)	0	2 (100)	0	Bielschowsky: 100 (16, 100) Thioflavin S: 100 (16, 96)	Bielschowsky: 100 (29, 100) Thioflavin S: 100 (63, 100)
Reader 2	Normal	0	3 (100)	0	8 (100)	0	8 (100)	Overall: 100 (16, 100)	Overall: 100 (63, 100)
Reader 3	Abnormal	2 (100)	0	2 (100)	0	2 (100)	0	Bielschowsky: 100 (16, 100) Thioflavin S: 100 (16, 100)	Bielschowsky: 100 (29, 100) Thioflavin S: 100 (63, 100)
Reader 3	Normal	0	3 (100)	0	8 (100)	0	8 (100)	Overall: 100 (16, 100)	Overall:100 (63, 100)
Majority read	Abnormal	2 (100)	0	2 (100)	0	2 (100)	0	Bielschowsky: 100 (16, 100) Thioflavin S: 67 (22, 96)	Bielschowsky: 100 (29, 100) Thioflavin S: 100 (66, 100)
Majority read	Normal	0	3 (100)	0)	8 (100)	0	8 (100)	Overall: 100 (40, 100)	Overall: 100 (72, 100)