Table 2.
Association between SLC23A2 genotypes and severe acute leukopenia, stomatitis, and cheilitis in 49 patients after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy.
| Leukopenia | Stomatitis | Cheilitis | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| severe | not severe | p | severe | not severe | p | severe | not severe | p | ||||
| rs2681116 | TT | 4 | 5 | 0.540 | 2 | 7 | 0.291 | 1 | 8 | 0.250 | ||
| TC | 13 | 14 | 2 | 25 | 3 | 24 | ||||||
| CC | 4 | 9 | 3 | 10 | 4 | 9 | ||||||
| rs13037458 | AA | 6 | 6 | 0.446 | 3 | 9 | 0.399 | 1 | 11 | 0.070 | ||
| AC | 14 | 17 | 3 | 28 | 4 | 27 | ||||||
| CC | 1 | 5 | 1 | 5 | 3 | 3 | ||||||
| rs1715364 | TT | 1 | 3 | 0.123 | 0 | 4 | 0.832 | 0 | 4 | 0.344 | ||
| TC | 8 | 17 | 3 | 22 | 6 | 19 | ||||||
| CC | 12 | 8 | 4 | 16 | 2 | 18 | ||||||
| rs4987219 | GG | 2 | 0 | 0.025 | 1 | 1 | 0.168 | 1 | 1 | 0.105 | ||
| GC | 3 | 12 | 3 | 12 | 4 | 11 | ||||||
| CC | 16 | 16 | 3 | 29 | 3 | 29 | ||||||
| rs1110277 | GG | 0 | 2 | 0.612 | 2 | 0 | 0.019 | 1 | 1 | 0.062 | ||
| GA | 9 | 10 | 2 | 17 | 5 | 14 | ||||||
| AA | 12 | 16 | 3 | 25 | 2 | 26 | ||||||
The rates of severe acute leukopenia, stomatitis, and cheilitis were 42.9% (21/49), 14.3% (7/49) and 16.3% (8/49), respectively. Frequencies in patients with these toxicities were compared with those without. Significance was assessed using Fisher's exact test.