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. 2014 Feb 11;11(4):337–343. doi: 10.7150/ijms.7861

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Serum aminotransferases, cytokines, and hepatic myeloperoxidase among different groups. Figure A showed serum ALT and AST levels significantly increased when 20 IU/ml of l.5ml/kg of ulinastatin pretreated ( UPC ) group or combined with 100μg of anti-HMGB1 (UPC+Anti-HMGB1 group) compared to those in control (p<0.05), but there was no significant difference between control group and UPC+rHMGB1 group (p>0.05). As showed in figure B and C, significantly increasing serum cytokines TNF-α and IL-1 levels were found in the control group and the UPC+rHMGB1 group compared with UPC group and UPC+Anti-HMGB1 group (p<0.05). At 120 min after reperfusion, rats in UPC and UPC plus Anti-HMGB1 had significantly reduced levels of myeloperoxidase (MDA) in liver homogenates compared to those in control as showed in figure D. Values are mean ± SD of 10 animals in each group. * P < 0.05 vs. Control.