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. 2014 Feb 11;11(4):337–343. doi: 10.7150/ijms.7861

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Effect of ulinastatin preconditioning (UPC) on attenuating liver ischemia reperfusion injury. Liver tissue was processed with H&E staining for light microscopy. Photograph depicts typical pattern of focal necrosis (black arrows) after ischemic degeneration of hepatocytes around the central venous area. Areas of necrosis were significantly lower in UPC and Anti-HMGB1 treated groups than in control. Magnification: 200×. Scale bar = 200μm. Hepatocyte apoptosis was determined by immunohistochemical analysis by microscopy after TUNEL staining. Photograph depicts typical pattern of apoptotic cells (black arrows). Percentage of apoptotic cells was significantly lower in UPC and Anti-HMGB1 treated groups than in control group. Magnification: 200×. Scale bar = 200μm.