Table 3.

Mortality figures and crude, propensity score adjusted and traditionally adjusted subdistribution hazard ratios (sHR) for radiotherapy versus radical prostatectomy for deaths from prostate cancer and other causes, stratified by risk group

Cause of death by risk group	No of events/Total No (%)		Radiotherapy versus surgery
			Crude sHR (95% CI)	P value	Propensity score adjusted sHR (95% CI)	P value	Traditional covariate adjusted sHR (95% CI)	P value
	Radiotherapy	Surgery
Risk group 1:
Prostate cancer	32/3039 (1.1)	44/10 003 (0.4)	2.16 (1.37 to 3.42)	<0.001	1.91 (1.16 to 3.14)	0.011	2.03 (1.22 to 3.40)	0.007
Other causes	223/3039 (7.3)	412/10 003 (4.1)	1.67 (1.42 to 1.97)	<0.001	1.26 (1.05 to 1.51)	0.013	1.24 (1.04 to 1.48)	0.019
Risk group 2:
Prostate cancer	142/4030 (3.5)	131/8125 (1.6)	1.95 (1.53 to 2.47)	<0.001	1.77 (1.37 to 2.29)	<0.001	1.77 (1.36 to 2.30)	<0.001
Other causes	376/4030 (9.3)	365/8125 (4.5)	1.94 (1.68 to 2.24)	<0.001	1.43 (1.23 to 1.68)	<0.001	1.40 (1.19 to 1.64)	<0.001
Risk group 3:
Prostate cancer	418/5040 (8.3)	118/2609 (4.5)	1.69 (1.38 to 2.07)	<0.001	1.50 (1.19 to 1.88)	<0.001	1.63 (1.28 to 2.06)	<0.001
Other causes	458/5040 (9.1)	154/2609 (5.9)	1.42 (1.18 to 1.70)	<0.001	1.20 (0.98 to 1.48)	0.081	1.20 (0.97 to 1.48)	0.091
Non-metastatic (risk groups 1-3):
Prostate cancer	592/12 109 (4.9)	293/20 737 (1.4)	3.09 (2.69 to 3.56)	<0.001	1.76 (1.49 to 2.08)	<0.001	1.77 (1.49 to 2.09)	<0.001
Other causes	1057/12 109 (8.7)	931/20 737 (4.5)	1.77 (1.62 to 1.93)	<0.001	1.32 (1.18 to 1.47)	<0.001	1.28 (1.16 to 1.42)	<0.001
Risk group 4:
Prostate cancer	102/817 (12.5)	43/389 (11.1)	1.04 (0.73 to 1.48)	0.835	0.76 (0.49 to 1.19)	0.231	0.65 (0.40 to 1.05)	0.081
Other causes	65/817 (8.0)	40/389 (10.3)	0.71 (0.48 to 1.05)	0.089	0.77 (0.45 to 1.34)	0.362	0.61 (0.35 to 1.07)	0.087