Table 5.
Required effect (subdivision hazard ratio, sHR) of hypothetical unmeasured confounder to give observed propensity score adjusted sHR of radiotherapy versus radical prostatectomy assuming no difference between cancer treatments
| Risk categories | Propensity score adjusted sHR (95% CI) | Assumed prevalence (%) of unmeasured confounder in surgery cohort | Assumed prevalence (%) of unmeasured confounder in radiotherapy cohort | |||
|---|---|---|---|---|---|---|
| 30 | 50 | 70 | 90 | |||
| Required confounder sHR to produce observed radiotherapy v surgery sHR | ||||||
| Group 1 | 1.91 (1.16 to 3.14) | 10 | 9.37 | 3.95 | 2.79 | 2.29 |
| 30 | — | Not possible | 8.19 | 3.79 | ||
| 50 | — | — | Not possible | Not possible | ||
| 70 | — | — | — | Not possible | ||
| Group 2 | 1.77 (1.37 to 2.29) | 10 | 7.30 | 3.40 | 2.48 | 2.07 |
| 30 | — | Not possible | 5.60 | 3.10 | ||
| 50 | — | — | Not possible | 58.15 | ||
| 70 | — | — | — | Not possible | ||
| Group 3 | 1.50 (1.19 to 1.88) | 10 | 4.32 | 2.43 | 1.91 | 1.67 |
| 30 | — | 10.92 | 2.99 | 2.11 | ||
| 50 | — | — | Not possible | 4.32 | ||
| 70 | — | — | — | Not possible | ||
| Non-metastatic (groups 1-3) | 1.76 (1.49 to 2.08) | 10 | 7.12 | 3.34 | 2.45 | 2.05 |
| 30 | — | Not possible | 5.41 | 3.04 | ||
| 50 | — | — | Not possible | 38.59 | ||
| 70 | — | — | — | Not possible | ||