Table 8.
Parameters | Main group (mg/kg/day) | Recovery group (mg/kg/day) | ||||
---|---|---|---|---|---|---|
|
|
|||||
0 | 500 | 1000 | 2000 | 0 | 2000 | |
| ||||||
Body weights (g)a) | 419.93 ± 15.09 | 459.35 ± 53.46 | 434.28 ± 23.35 | 439.99 ± 31.47 | 461.03 ± 23.01 | 503.19 ± 25.81* |
Adrenal gland-left | 0.024 ± 0.002 | 0.028 ± 0.003** | 0.025 ± 0.003 | 0.028 ± 0.004* | 0.025 ± 0.002 | 0.023 ± 0.009 |
% to body weight | 0.006 ± 0.001 | 0.006 ± 0.001 | 0.006 ± 0.001 | 0.006 ± 0.001 | 0.006 ± 0.000 | 0.005 ± 0.002 |
Adrenal gland-right | 0.023 ± 0.003 | 0.028 ± 0.004** | 0.024 ± 0.003 | 0.027 ± 0.003* | 0.026 ± 0.002 | 0.027 ± 0.003 |
% to body weight | 0.006 ± 0.001 | 0.006 ± 0.000 | 0.006 ± 0.001 | 0.006 ± 0.001 | 0.006 ± 0.000 | 0.005 ± 0.001 |
Pituitary gland | 0.011 ± 0.001 | 0.012 ± 0.002 | 0.012 ± 0.001 | 0.012 ± 0.002 | 0.012 ± 0.001 | 0.013 ± 0.001 |
% to body weight | 0.003 ± 0.000 | 0.003 ± 0.000 | 0.003 ± 0.000 | 0.003 ± 0.000 | 0.003 ± 0.000 | 0.003 ± 0.000 |
Thymus | 0.307 ± 0.070 | 0.316 ± 0.061 | 0.285 ± 0.057 | 0.285 ± 0.064 | 0.235 ± 0.061 | 0.265 ± 0.041 |
% to body weight | 0.073 ± 0.016 | 0.069 ± 0.013 | 0.066 ± 0.015 | 0.065 ± 0.015 | 0.051 ± 0.011 | 0.053 ± 0.009 |
Prostate gland | 0.595 ± 0.094 | 0.651 ± 0.1070 | 0.644 ± 0.094 | 0.583 ± 0.116 | 0.658 ± 0.051 | 0.691 ± 0.210 |
% to body weight | 0.142 ± 0.022 | 0.144 ± 0.029 | 0.149 ± 0.023 | 0.133 ± 0.028 | 0.142 ± 0.017 | 0.139 ± 0.045 |
Testis-left | 1.921 ± 0.352 | 1.995 ± 0.176 | 2.007 ± 0.107 | 2.105 ± 0.163 | 2.125 ± 0.140 | 2.158 ± 0.169 |
% to body weight | 0.458 ± 0.085 | 0.438 ± 0.053 | 0.463 ± 0.030 | 0.480 ± 0.044 | 0.462 ± 0.040 | 0.429 ± 0.032 |
Testis-right | 2.026 ± 0.157 | 2.047 ± 0.151 | 2.026 ± 0.087 | 2.108 ± 0.160 | 2.125 ± 0.094 | 2.196 ± 0.163 |
% to body weight | 0.483 ± 0.037 | 0.449 ± 0.043 | 0.468 ± 0.027 | 0.481 ± 0.044 | 0.462 ± 0.035 | 0.438 ± 0.043 |
Epididymis-left | 0.631 ± 0.100 | 0.689 ± 0.075 | 0.672 ± 0.037 | 0.704 ± 0.048 | 0.726 ± 0.018 | 0.749 ± 0.048 |
% to body weight | 0.150 ± 0.023 | 0.151 ± 0.016 | 0.155 ± 0.007 | 0.161 ± 0.014 | 0.158 ± 0.010 | 0.149 ± 0.015 |
Epididymis-right | 0.687 ± 0.058 | 0.720 ± 0.055 | 0.700 ± 0.053 | 0.706 ± 0.041 | 0.742 ± 0.035 | 0.771 ± 0.026 |
% to body weight | 0.164 ± 0.011 | 0.158 ± 0.015 | 0.161 ± 0.010 | 0.161 ± 0.012 | 0.161 ± 0.012 | 0.154 ± 0.012 |
Spleen | 0.828 ± 0.106 | 0.912 ± 0.158 | 0.833 ± 0.122 | 0.856 ± 0.091 | 0.830 ± 0.122 | 0.894 ± 0.074 |
% to body weight | 0.197 ± 0.023 | 0.198 ± 0.021 | 0.192 ± 0.023 | 0.195 ± 0.014 | 0.180 ± 0.012 | 0.178 ± 0.020 |
Kidney-left | 1.245 ± 0.081 | 1.395 ± 0.149* | 1.286 ± 0.077 | 1.359 ± 0.143* | 1.323 ± 0.054 | 1.406 ± 0.063 |
% to body weight | 0.297 ± 0.020 | 0.304 ± 0.017 | 0.296 ± 0.012 | 0.309 ± 0.018 | 0.287 ± 0.013 | 0.280 ± 0.021 |
Kidney-right | 1.298 ± 0.102 | 1.390 ± 0.122 | 1.294 ± 0.066 | 1.376 ± 0.134 | 1.342 ± 0.060 | 1.456 ± 0.075* |
% to body weight | 0.309 ± 0.027 | 0.304 ± 0.019 | 0.298 ± 0.012 | 0.312 ± 0.012 | 0.292 ± 0.017 | 0.290 ± 0.021 |
Heart | 1.413 ± 0.095 | 1.516 ± 0.205 | 1.406 ± 0.076 | 1.466 ± 0.118 | 1.488 ± 0.149 | 1.616 ± 0.099 |
% to body weight | 0.337 ± 0.024 | 0.330 ± 0.016 | 0.324 ± 0.017 | 0.333 ± 0.019 | 0.322 ± 0.018 | 0.321 ± 0.019 |
Lung | 1.727 ± 0.130 | 1.849 ± 0.177 | 1.746 ± 0.153 | 1.724 ± 0.127 | 1.793 ± 0.107 | 1.963 ± 0.111* |
% to body weight | 0.411 ± 0.026 | 0.404 ± 0.028 | 0.402 ± 0.028 | 0.392 ± 0.009 | 0.390 ± 0.035 | 0.391 ± 0.035 |
Brain | 1.945 ± 0.077 | 2.007 ± 0.102 | 1.973 ± 0.090 | 1.992 ± 0.069 | 1.915 ± 0.071 | 2.066 ± 0.098* |
% to body weight | 0.464 ± 0.028 | 0.440 ± 0.033 | 0.455 ± 0.026 | 0.454 ± 0.025 | 0.416 ± 0.030 | 0.411 ± 0.024 |
Liver | 10.580 ± 0.578 | 12.072 ± 1.729 | 11.034 ± 0.800 | 11.860 ± 1.453 | 10.970 ± 0.629 | 12.379 ± 0.803* |
% to body weight | 2.521 ± 0.135 | 2.622 ± 0.119 | 2.540 ± 0.108 | 2.690 ± 0.189* | 2.380 ± 0.087 | 2.460 ± 0.0791 |
No. of animals | 10 | 10 | 10 | 10 | 5 | 5 |
*/** Significantly different from control at p < 0.05/ p < 0.01. Values are mean ± S.D.
a)Body weights were measured right before necropsy after an overnight fast.