Table 14.

Observations of micronucleus and PCE: RBC ratio

Dose (mg/kg/day)	Animals per dose	MNPCE/2000 PCE (Mean ± S.D)	PCE:RBC Ratio (Mean ± S.D)	% Ratio
0	6	1.17 ± 0.75	0.40 ± 0.02	100
1250	6	0.83 ± 0.98	0.38 ± 0.03	95
2500	6	0.83 ± 0.75	0.37 ± 0.03	93
5000	6	0.83 ± 0.75	0.39 ± 0.02	98
CPA 70 (mg/kg)	6	61.00 ± 5.18**	0.21 ± 0.03**	53

PCE; Polychromatic erythrocyte, RBC; Red blood cells (polychromatic erythrocyte + normochromatic erythrocyte), MNPCE; Micronucleated polychromatic erythrocyte, CPA; Cyclophosphamide monohydrate.

Vehicle and Test article were orally administered to mice for two consecutive days.

CPA was intraperitoneally administered to mice once on the day of the 2^nd admin.

Bone marrow smears were prepared about 24 hr after the final administration.

** Significantly different from the negative control group at p<0.01.