Figure 6. DN SIRT1-expressing adenovirus infection abrogates IFN-β-induced protection against LPS-induced lethal shock.

C57BL/6 mice were randomly grouped and injected with DN SIRT1 expressing adenovirus (1 × 10¹⁰ MOI). Two days later, the mice were injected with vehicle or IFN-β (1000 U/20 g) and 30 min later further injected with 18 mg/kg body weight of LPS. Full-length blots are presented in Supplementary Figure S10. The Western blot shown is a representative of three independent experiments.