Table 4.
Study results | Reference |
---|---|
Ras is expressed in GEP-NENs but mutations are rare | 21, 263-266 |
Raf mutations are rare events | 263, 305-307 |
Rap1 and B-Raf are highly expressed in GEP-NEN | 309 |
Raf inhibition triggers feedback activation of Akt | 135, 310, 311 |
MAPK signaling triggers NE secretion and migration in vitro |
312-314 |
Raf activation induces a paradox inhibition of proliferation and NE secretion | 318-321 |
ERK activation is frequent in GEP-NENs | 6, 263, 309, 361 |