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Table 2.

Summary of Changes Observed in Young RAG1 KO after Receiving CD4⁺ T Cells Isolated from Young (8 weeks) and Old (24 months) Mice of Both Sexes

Donor age compared with young donor	Old mice	Significant sex effect/time point
GC density	↓^∗	F = M
CD4⁺ T-cell infiltration in conjunctiva	↑^∗	M >> F
CD4⁺ T-cell infiltration in LG	↑^∗	M >> F

F, female; M, male; GC, goblet cell; LG, lacrimal gland; ND, not determined; RAG1 KO, recombination activating gene-1 knockout; ↑, increase; ↓, decrease.

^∗

P ≤ 0.05 compared to young (8 weeks old) mice.