Table II.

Binding partner-specific interface prediction using RCF

Unbound PDB	Bound PDB_chain	Unique interface fraction (σ)	AUCa for the entire interface	Random prediction for the entire interface	AUCa for partner-specific interface residues (σ)	Random predictio n for partner-specific interface residues
1QG4 (Ran GTPase)	1A2K_C	0.53	0.75	0.08	0.54	0.05
	1I2M_A	0.72	0.61	0.14	0.58	0.10
1AUQ (von Willebrand Factor A1)	1IJK_A	0.86	0.24	0.10	0.50	0.09
	1M10_A	0.91	0.61	0.16	0.54	0.15
2CGA (Chymotrypsin)	1ACB_E	0.00	0.59	0.09	NA	NA
	1CGI_E	0.28	0.74	0.13	0.14	0.04
1JAE (α-amylase)	1CLV_A	0.35	0.68	0.09	0.09	0.03
	1TMQ_A	0.35	0.77	0.09	0.12	0.03
1TFH (Tissue factor)	1AHW_C	0.16	0.15	0.22	0.02	0.19
	1JPS_T	0.13	0.11	0.15	0.01	0.12
1C3D (Complement C3)	1GHQ_A	1.00	0.03	0.05	0.03	0.05
	3D5S_A	1.00	0.11	0.09	0.12	0.09
1IJJ (Actin)	1KXP_A	0.64	0.51	0.11	0.23	0.07
	2BTF_A	0.46	0.62	0.07	0.22	0.03
1YJ1 (Ubiquitin)	1S1Q_B	0.35 (0.076)	0.83	0.52	0.19(0.052)	0.19
	1XD3_B	0.41 (0.018)	0.82	0.54	0.20(0.031)	0.22
	2OOB_B	0.09 (0.078)	0.89	0.39	0.07(0.011)	0.04
3LZT (Hen lysozyme)	1BVK_F	0.82 (0.175)	0.53	0.16	0.41(0.117)	0.13
	1DQJ_C	0.72 (0.288)	0.35	0.20	0.27(0.073)	0.14
	1MLC_E	0.83 (0.288)	0.11	0.14	0.12(0.038)	0.12
	2I25_L	0.85 (0.090)	0.80	0.47	0.66(0.103)	0.40
1MH1 (Rac GTPase)	1E96_A	0.81 (0.084)	0.32	0.10	0.42(0.096)	0.08
	1HE1_C	0.55 (0.191)	0.64	0.14	0.21(0.034)	0.08
	1I4D_D	0.47 (0.256)	0.92	0.11	0.31(0.245)	0.05
	2FJU_B	0.37 (0.244)	0.74	0.07	0.18(0.239)	0.03
	2H7V_A	0.43 (0.299)	0.67	0.11	0.22(0.051)	0.05
	2NZ8_A	0.48 (0.208)	0.73	0.14	0.14(0.033)	0.07

^aAUC stands for Area Under the Precision-Recall Curve

(σ) Standard deviations are provided in parentheses for proteins with more than two binding partners.